Animal Models of Drug Addiction - download pdf or read online

By Styliani Vlachou, Athina Markou (auth.), Mary C. Olmstead (eds.)

ISBN-10: 1607619334

ISBN-13: 9781607619338

Our realizing of habit and the way it truly is handled has complicated remarkably over the last a long time, and lots more and plenty of the growth is expounded on to animal learn. this is often real for either the behavioural elements of drug use in addition to the organic underpinnings of the sickness. In Animal versions of Drug habit, specialists within the box supply an updated evaluate of complicated behavioural paradigms that version various phases of this affliction and clarify how every one try is used to successfully mirror the development of drug habit. This specific and useful publication starts with the most typical laboratory measures of habit in animals, together with intracranial self-stimulation (ICSS), drug self-administration, position conditioning, and sensitization. Later chapters describe how those paradigms are used to version the development of drug habit, delivering perception into the scientific symptomatology of dependancy from acquisition of drug use via compulsive drug taking to withdrawal and relapse. Written for the preferred Neuromethods sequence, the contributions supply either methodological element and a theoretical point of view, attractive to readers conversant in preclinical study on drug dependancy in addition to those people who are newbies to the sphere. state-of-the-art and authoritative, Animal types of Drug habit will function a foundation for destiny important learn that hyperlinks the bench to the bedside within the the most important therapy of drug addiction.

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25 mg/kg (50) or 1 mg/kg (180) nicotine administration, with no effect on response latencies (50) or a small reward-facilitating effect (164). The same dose of nicotine (1 mg/kg) had no effect in a progressive-ratio ICSS procedure (180). 03 mg/kg/infusion) self-administered for 1 or 12 h daily led to a long-lasting reward-enhancing effect, reflected by lowered ICSS thresholds during the nicotine selfadministration days (before and after the daily nicotine selfadministration session) that persisted for more than 1 month after self-administration ceased (48).

8 g/kg, the ICSS response rate and total time spent self-­ stimulating increased. Higher ethanol doses induced a dramatic and long-lasting decrease of both response rates and time selfstimulating (270). 7 g/kg) when behavior was disrupted (274, 275). The route of ethanol administration (intraperitoneal or intragastric) appeared to affect the effects of ethanol on brain stimulation reward, demonstrated by a reduction in the response rate after intragastric administration (274). Additionally, chronic ethanol administration in the form of an ethanol liquid diet led to reduced responding in the 5% alcohol-containing diet group compared with the control diet groups (275).

5–10 mg/kg, IP) dose-dependently lowered ICSS thresholds of the ventral pallidum or lateral hypothalamus in the rate-frequency curve-shift procedure (112, 114), and this effect was not as pronounced when the animals were treated with methylphenidate during early developmental stages (120). 5–20 mg/kg, IP) dose-­dependently lowered brain stimulation reward thresholds (115), whereas repeated administration of high-dose cocaine (40 mg/kg) decreased response rates and elevated thresholds (105). Consistent with one of the advantages of ICSS is the finding that these effects of cocaine are independent of the psychomotor stimulant effects of cocaine.

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Animal Models of Drug Addiction by Styliani Vlachou, Athina Markou (auth.), Mary C. Olmstead (eds.)


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